Conditions of withdrawal

Venous blood sampling (most often at the bend of the elbow). No specific recommendations. Dosage possible during pregnancy in maternal blood (in this case indicate the precise number of weeks of pregnancy) and in parallel in the amniotic fluid (amniocentesis, which is performed only in a particular context of pregnancy at risk, between 14th and 16th week of pregnancy).

Interest of the dosage

A-Fetoprotein is a glycoprotein present in the serum of the fetus, it normally disappears in the weeks following the birth, a small part passes into maternal blood during pregnancy. Dosage in maternal blood and amniotic fluid will be performed in high-risk pregnancies to look for a neural tube abnormality in the fetus or other malformations. On the other hand, α-fetoprotein is a marker Tumor increased in certain cancers, in particular hepatocellular and testicular.

Pathological variations

Caution: interpretation of the delicate levels in pregnant women and in the amniotic fluid due to the imprecision of the date of pregnancy, possible overlap between normal and pathological concentrations, contamination of the amniotic fluid with fetal blood

Amniotic fluid and serum pregnant woman

Adult serum

Serum in adults: