· Hypertension, arterial.

· Prophylaxis of angina attacks, stress.

· Treatment of certain disorders of the rhythm: supraventricular (tachycardia, flutters and atrial fibrillations, junctional tachycardia) or ventricular (ventricular extrasystolia, tachycardia, ventricular) Code>
· Hypertension: The usual daily dose of acebutolol is 400 mg, which is given either as a single dose each morning (400 mg) or in two doses, One in the morning and one in the evening This dose may be increased in case of severe hypertension

· Prophylaxis of stress angina attacks, tachyarrhythmias, daily dose may range from 400 to 800 mg (600 mg, on average), starting with the lowest dose, and adapting gradually Dosage in the clinical state or at the electrocardiogram.

Film-coated tablet

BETA-BLOCKING / SELECTIVE

(C07AB04: system, cardiovascular).

Acebutolol is characterized by three pharmacological properties

· Activity, beta-blocking beta-1 selective

· Antiarrhythmic effect

· Partial agonist potency (intrinsic sympathomimetic activity, moderate).

Not applicable.

This medicinal product MUST NEVER be used in the following cases

· Asthma and chronic obstructive pulmonary disease in their severe forms

· Cardiac insufficiency not controlled by the treatment.

· Cardiogenic shock.

· Atrioventricular blocks of the second and third degrees, not paired.

· Prinzmetal Angina (in pure and monotherapy forms).

· Sinus disease (including sino-atrial block).

· Bradycardia (

Breastfeeding

In the case of treatment with acebutolol, breast-feeding is contraindicated due to a significant passage in milk (see section 'Pharmacokinetic properties').

At the clinical level

The most frequently reported

· Asthenia

· Cooling of the ends

· Bradycardia, severe if necessary

· Digestive disorders (gastralgia, nausea, vomiting)

· Impotence

Much more rarely

· Decreased conduction, atrioventricular or intensification of a block, existing atrio-ventricular

· Heart failure

· Blood pressure drop

· Bronchospasm

· Hypoglycaemia

· Raynaud's syndrome

· Aggravation of an existing intermittent claudication

· Various manifestations, including skin, including psoriasiform eruptions, or exacerbation of psoriasis (see Precautions)
· Exceptionally, pneumopathies of immuno-allergic origin.

Biologically speaking

In rare cases, the appearance of antinuclear antibodies accompanied only by exceptional clinical manifestations in the form of lupus syndrome and which led to discontinuation of treatment.

· Treatment of certain disorders of the rhythm: supraventricular (tachycardia, flutters and atrial fibrillations, junctional tachycardias) or ventricular (ventricular extrasystolia, tachycardia; Ventricular lesions).