Treatment of high blood pressure

Treatment of chronic angina, stable.

Tablets containing 5 mg of bisoprolol hemifumarate are intended for oral administration.

The dosage should be adjusted individually. It is recommended to start with the lowest dose possible. In some patients, a dosage of 5 mg per day may be sufficient. The usual dose is 10 mg once daily and the recommended maximum dose is 20 mg per day.
In case of renal insufficiency

In patients with renal insufficiency, severe (creatinine clearance, less than 20 ml / min) the dose should not exceed 10 mg once daily. This dosage may optionally be divided by 2.

In case of severe hepatic impairment

In the case of severe hepatic insufficiency, the dosage should not exceed 10 mg of bisoprolol once a day.
Elderly subjects

As a rule, dosage adjustment is not necessary. It is recommended to start with the lowest dose possible.

Children under 12 and adolescents under 18 years of age

Since this medicinal product has not been used in pediatric patients, it is not recommended for use in children.
Stop processing

Treatment should not be interrupted abruptly (see Warnings and Precautions for Use). The dosage should be decreased gradually by reducing it by half in one-week increments.
White, round, convex film-coated tablets with the following identification marking: BISOPROLOL 5 engraved on one side

Class: Pharmacotherapeutic: beta-blockers beta-1, cardioselective, ATC code: C07AB07.
Bisoprolol is a potent, beta-blocker having a high affinity for beta-1 receptors and lacking intrinsic sympathomimetic activity., As with other beta-blockers, its mechanism of action in hypertension, Is not quite elucidated. However, we know that bisoprolol, strongly decreases the activity of plasma renin

In angina patients, blocking of beta receptors reduces cardiac activity and, as a result, oxygen requirements.

Bisoprolol has similar local anesthetic properties to those of propranolol.

In a study in patients with ischemic heart disease, bisoprolol did not alter the ability to drive. However, due to intra-individual variations in reactions to the drug, the ability to drive and use machines can be altered. This effect must be taken into account, in particular at the beginning of the treatment, when the treatment is modified and in case of alcohol consumption.
Bisoprolol is contraindicated in the following cases

· Hypersensitivity to the active substance or to any of the excipients listed in section Composition.
· Acute heart failure during episodes of decompensation of heart failure requiring IV inotropic treatment

· Cardiogenic shock.

· Atrio-ventricular blocks of the 2nd and 3rd degrees (not paired).
· Sinus disease.

· Sino-atrial block.

· Symptomatic bradycardia (