This medication is indicated in case of moderate hair loss (alopecia, androgenetic) of adult, male or female. It promotes hair growth and stabilizes the phenomenon of falling

Application of dermal

RESERVED FOR THE ADULT

Apply a dose of 1 ml twice a day to the scalp starting from the center of the area to be treated

The daily dose should not exceed 2 ml

Extend the product with your fingertips so as to cover the entire area to be treated (see application mode according to the delivery system).
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Before and after application of the solution, wash hands thoroughly.

Apply to perfectly dry hair and scalp.

The method of application varies according to the delivery system used with the vial.
Sprayer: This system is suitable for application on extended surfaces.

1 - Remove the outer cap from the bottle

2 - Unscrew and remove the cap, inside.

3 - Insert the sprayer into the bottle, screw it firmly and remove the small cap, transparent

4 - For application: direct the sprayer to the center of the surface to be treated, press once and extend the product with the tip of the fingers. Repeat the procedure 6 times to apply a dose of 1 ml.
Avoid inhaling the product.

Replace the cap on the bottle after use.

Sprayer equipped with an applicator: this system is suitable for application on small surfaces or under the hair.

1 - Remove the outer cap from the bottle

2 - Unscrew and remove the cap, inside.

3 - Insert the sprayer into the bottle, screw it firmly and remove the small cap, transparent

4 - Firmly pull upwards to remove the "head" (carrying an arrow) from the sprayer.
5 - Insert the applicator onto the sprayer rod (now headless) and push fully. Remove the cap (plastic, transparent) from the end of the applicator.

6 - For application: direct the sprayer to the center of the surface to be treated, or under the hair, press once and spread the product with fingertips. Repeat the operation 6 times to apply a dose of 1 ml.
Avoid inhaling the product.

Replace the small transparent cap on the end of the applicator after use.

Pharmacotherapeutic group: MINOXIDIL FOR USE, LOCAL (D: dermatological drugs)

Efficacy and tolerability in subjects less than 18 years of age and over 65 years have not been studied

Applied topically, minoxidil stimulates the growth of keratinocytes in vitro, and in vivo and hair growth in some individuals with androgenetic alopecia.



The occurrence of this phenomenon takes place after about 4 months (or more) of use of the product and varies according to the subjects.

When the treatment is stopped, the regrowth ceases and a return to the state is predictable within 3 or 4 months.

The precise mechanism of action is not known. Topical application of minoxidil in controlled clinical trials in normotensive or hypertensive patients did not result in the observation of systemic manifestations related to absorption of minoxidil

Without object.

Hypersensitivity to minoxidil or to any of the other ingredients of the solution

Warnings, special

Before using topical minoxidil, the subject should ensure that his or her scalp is normal and healthy.


· Dermatosis or lesion of the scalp

· Concomitant use of retinoic acid, anthralin or any other irritant topical

· Increase of the applied dose and / or increase in the frequency of applications: it is imperative to respect the dosage and the method of administration.
Similarly, although extensive use of minoxidil solution has not revealed any systemic effects, it can not be ruled out that greater absorption due to unusual individual variability or sensitivity may cause systemic effects . Patients should be warned.

In the event of systemic effects (decreased blood pressure, tachycardia, signs of fluid retention, pain, chest) or severe dermatological reactions, treatment should be interrupted.

In subjects with a cardiac history, the benefit of treatment should be weighed.

They should be more particularly aware of potential adverse effects in order to discontinue treatment at the onset of one of them and notify a doctor.
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Do not apply minoxidil

· In the event of sudden hair loss, hair loss, consequence of disease or treatment, medicinal product

· On another part of the body

Precautions for use

Accidental ingestion is likely to cause undesirable effects, including severe cardiac (see section 4.4).


In the event of accidental contact with the eye, injured skin, mucosa, the solution (containing ethanol) may cause burning and irritation: rinse with plenty of running water. >

Solar exposure is not recommended when minoxidil is applied.

This medicinal product contains propylene glycol and may cause skin irritation.


Without object.

Adverse ingestion may cause systemic effects due to vasodilator action: minoxidil (5 ml solution contains 100 mg minoxidil, the maximum dose used for oral administration in adults treated for hypertension; Arterial pressure). Signs of symptoms of a possible overdose would be cardiovascular, with decreased blood pressure, tachycardia and retention, hydrosodic. A hydrosodic retention may be treated with a suitable therapeutic, diuretic, tachycardia and angina by a beta blocker or other sympathetic nervous system inhibitor. Symptomatic hypotension could be treated by intravenous administration of isotonic sodium chloride solution. The use of sympathomimetics, such as norepinephrine and adrenaline due to excessive cardiac stimulation, should be avoided.

Pregnancy

Studies in animals have not shown any teratogenic effect. In the absence of teratogenic effect in animals, a malformative effect in the human species is not expected. Indeed, to date, the substances responsible for malformations in the human species have been found to be teratogenic in animals in well-conducted studies of two species

In clinical studies, there is currently no adequate data to evaluate a possible malformative or fetotoxic effect of minoxidil when administered during pregnancy.
Therefore, as a precautionary measure, it is preferable not to use minoxidil during pregnancy.


Generally, minoxidil passes into breast milk, therefore the medication should be avoided in the nursing woman.


· Minor skin reactions: local irritation with, in particular, desquamations, erythema, dermatitis, dry skin, hypertrichosis (remote), burning and pruritus (especially due to the presence of ethanol), acne.

· Breathing problems: dyspnea

More rarely

Allergy (sensitivity, rhinitis, rash, generalized erythema, edema of the face)

· Vertigo

· Tingling

· Headache

· Weakness

· Neuritis

· Edema

· Alteration of taste

· Ear infection (especially otitis externa)

· Disorders of vision

· Eye irritation

· Cardiovascular disorders (palpitations, heart rhythm, accelerated, chest pain)

Finally, it could be reported a few cases of alopecia, irregular hair, and alteration of blood pressure.

It is possible that liver biological abnormalities occur.

It should be noted, however, that these medical events, especially those which have been most rarely reported, have been reported without formal accountability for treatment. >

The topical application of minoxidil in clinical trials, controlled in normotensive or hypertensive patients, did not lead to the observation of systemic manifestations related to An absorption of minoxidil.

This medication is indicated in case of moderate hair loss (alopecia, androgenetic) of adult, male or female. It promotes hair growth and stabilizes the phenomenon of falling