They are mostly, feared at high doses or during a prolonged treatment over several months

Hydro-electrolyte disorders, hypokalemia, metabolic alkalosis, retention, hydrosodia, hypertension, congestive heart failure.

· Endocrine and metabolic disorders: Cushing's syndrome, iatrogen, ACTH secretion inertia, atrophy, adrenal cortex sometimes definitive, decrease, glucose tolerance, development of latent diabetes, Child, menstrual irregularities

Musculoskeletal disorders: muscular atrophy, preceded by muscle weakness (increased proteintic catabolism), osteoporosis, pathological fractures, especially vertebral fractures, aseptic osteonecrosis of the femoral heads.

· Digestive disorders: hiccups, peptic ulcers, small bowel ulcers, perforations and gastrointestinal haemorrhage, acute pancreatitis, have been reported, especially in children. Code>
· Skin disorders: acne, purpura, ecchymosis, hypertrichosis, delayed healing

· Neuropsychic disorders

O frequently: euphoria, insomnia, excitement

O rarely: maniac-like access, confusional or confusing-confronted states, convulsions (pathway, general or intrathecal)

O depressive state at cessation of treatment.

· Eye disorders: some forms of glaucoma and cataracts