Ways of administration

Direct intravenous route into the infusion tubing or continuous infusion. Any extravasation or accidental injection, subcutaneous can be generator, necrotic accident.

· Intra-arterial (hepatic artery).

· Local (intraseerous) way.

Mode of administration

A change in color of the solution from purple to pink may indicate denaturation of the molecule. This denaturation can be observed at a pH below 6 or in the presence of oxidants and reducing agents. For this latter reason, perfusion in a plastic bag is not recommended, as well as the association with other medicinal products in the perfusion bottle.
Reconstitution Volumes

Via the venous line

25 ml of solvent for 1 vial of 10 mg.

Concentration: 0.4 mg / ml.
Solvents: water for preparations, injectables or 0.9% NaCl solution, or glucose 5%.
Agitate until a clear solution is obtained.


The dosages vary according to the indications and the protocols of use.

By endo-vascular route, the total dose per cure is on average 10 to 15 mg / m 2.
The cures are spaced from 4 to 8 weeks with a total dose of 80 mg / m 2.
These mean doses can be increased according to tolerance and evolution.

The rate of administration varies according to the nature of the conditions treated.

In case of extravasation, the administration will be interrupted immediately.

Mode of handling

The preparation of injectable cytotoxic solutions must be carried out by specialized and trained personnel with knowledge of the medicines used under conditions ensuring the protection of the environment and especially the protection of the personnel handling. Requires a preparation room reserved for this purpose. It is forbidden to smoke, to eat, to drink in this room. Handlers shall be provided with a set of equipment suitable for handling, including long-sleeved gowns, masks, protective goggles, protective goggles, gloves for use, single sterile, worktop protection areas, containers and Garbage collection bags. The excreta and vomit must be handled with caution. Pregnant women should be warned, and avoid the manipulation of cytotoxics. Any broken container should be treated with the same precautions and regarded as a contaminated waste. The disposal of contaminated waste is carried out by incineration and in rigid containers labeled for this purpose

These provisions may be envisaged within the framework of the Cancerology Network (circular DGS / DH / 98 No. 98/188 of 24 March 1998) in collaboration with any suitable and meeting the requirements. >