· Symptomatic treatment of pain from mild to moderate and / or febrile states

· Chronic inflammatory arthritis, rheumatism, acute articular in children

· Symptomatic treatment of rheumatism, inflammatory in adults

Administration mode

Oral use.

Pour the contents of the sachet into a glass and add a small amount of drink (eg water, milk, fruit juice).
Dosage

Pain intensity, mild to moderate and / or febrile states

Reserved for adults and children from 30 kg (approximately 9 to 15 years).
In children, it is imperative to respect the dosages defined according to the weight of the child and to choose an adapted presentation The approximate ages according to the weight are given for information

The recommended daily dose of acetylsalicylic acid is approximately 60 mg / kg / day, divided into 4 or 6 doses, approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours .

· For children weighing 30 to 40 kg (approximately 9 to 13 years), the dosage is 1 sachet per dose, to be renewed if necessary after 6 hours, without exceeding 4 sachets per day. Code>
For children weighing 41 to 50 kg (approximately 12 to 15 years), the dosage is 1 sachet per dose, to be renewed if necessary after 4 hours, but not more than 6 sachets per day.

· For adults and children weighing more than 50 kg (from about 15 years) The maximum recommended daily dose is 3 g of acetylsalicylic acid, ie 6 sachets per day .; The usual dosage is 1 sachet to 500 mg, to be renewed if necessary after 4 hours minimum. In case of severe pain or fever, 2 sachets to 500 mg, to be renewed if necessary after 4 hours, minimum, not to exceed 6 sachets per day. >

The recommended maximum daily dose is 2 g of acetylsalicylic acid or 4 sachets per day The usual dosage is from 1 sachet to 500 mg, to be renewed if necessary at the end of 4 hours minimum. In case of severe pain or fever, 2 sachets to 500 mg, to be renewed if necessary after 4 hours, minimum, not to exceed 4 sachets per day. >

Frequency, Administration

Systematic catches avoid oscillations of pain or fever

· In adults: catches must be spaced at least 4 hours apart

In children: catches should be regularly spaced, including at night, preferably 6 hours, and at least 4 hours: follow the dosage as specified above
>

Duration of treatment: the patient should be advised not to use acetylsalicylic acid for more than 3 days in case of fever and 5 days in case of pain without notice of a doctor or dentist .

Rheumatic disorders

Reserved for adults and children up to 20 kg

· In adults: 3 to 6 g, maximum per day to be divided into 3 or 4, catches spaced at least 4 hours apart. In the elderly the dosage will be reduced.
In children: this presentation is reserved for children from 20 kg, 50 mg / kg to 100 mg / kg maximum per day to be distributed in 4 to 6 intakes spaced at least 4 hours apart < Code>
OTHER, ANALGESIC AND ANTIPYRETIC, ATC code N02BA01.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs with analgesic, antipyretic and anti-inflammatory properties. Its mechanism of action is based on the irreversible inhibition of cyclooxygenase enzymes involved in the synthesis of prostaglandins

Acetylsalicylic acid also inhibits platelet aggregation by blocking the platelet synthesis of thromboxane A 2.

No effect on the ability to drive and use machines has been observed.
This drug is COUNTER-INDICATED in the following situations

· Hypersensitivity to acetylsalicylic acid or to any of the excipients or to other anti-inflammatories · non-steroidal (cross-reactive)

· A history of asthma caused by the administration of salicylates or substances of proximate activity including non-steroidal anti-inflammatory drugs

· Third trimester of pregnancy (over 24 weeks of amenorrhea) for doses greater than 100 mg per day (see section Pregnancy and lactation)
>
· Evolving Gastroduodenal Ulcer

· Any constitutional or acquired hemorrhagic disease

· Risk of haemorrhage

· Severe hepatic impairment

· Severe renal impairment

· Severe heart failure not controlled

· In combination with methotrexate used at doses greater than 20 mg / week (see section Interactions with other medicinal products and other forms of interactions) and for anti-inflammatory doses (≥ 1 g; And / or ≥ 3 g per day) or for analgesic or antipyretic doses (≥ 500 mg per dose and / or
· In combination with oral anticoagulants for anti-inflammatory doses of acetylsalicylic acid (≥ 1 g per dose and / or ≥ 3 g daily), or for analgesic or antipyretic doses (≥ 500 mg per dose And / or

Warnings, special

In case of combination with other medicines, to avoid a risk of overdose, check the absence of acetylsalicylic acid in the composition of other medicines.
In the case of long-term administration of high-dose analgesic medicinal products, the occurrence of headache should not be treated with higher doses. >
The regular use of analgesics, in particular the combination of analgesics, may lead to persistent kidney damage, with a risk of renal insufficiency

Reye syndromes, very rare but life-threatening, have been observed in children and adolescents with signs of viral infections (in particular, varicella and episodes of influenza-like illness) and receiving 'acetylsalicylic acid. As a result, acetylsalicylic acid should only be administered to these children and adolescents on medical advice when other measures have failed. In the event of persistent vomiting, unconsciousness or abnormal behavior, treatment with acetylsalicylic acid should be discontinued.
In some cases of severe form of G6PD deficiency, high doses of acetylsalicylic acid may have resulted in hemolysis The administration of acetylsalicylic acid in cases of G6PD deficiency should be under medical supervision. Code>
In children less than 1 month of age, the administration of acetylsalicylic acid is justified only in certain situations falling within the scope of the medical prescription. >
Monitoring of treatment should be strengthened in the following cases

· History of gastroduodenal ulcer, digestive hemorrhage or gastritis

· Renal or hepatic impairment

· Asthma: The onset of asthma attacks in some individuals may be related to an allergy to nonsteroidal anti-inflammatory drugs or acetylsalicylic acid. In this case, this drug is contraindicated

· Bleeding or menorrhagia (risk of increasing the size and duration of menstruation)

Gastrointestinal haemorrhages or ulcers / perforations may occur at any time during treatment without there being necessarily prior symptoms or antecedents. The relative risk increases in the elderly, the subject with a low body weight, the patient undergoing anticoagulant or antiplatelet therapy (see Interactions with other medicinal products and other forms of interactions). In cases of gastrointestinal haemorrhage, immediately stop treatment.

In view of the effect of acetylsalicylic acid, which appears at very low doses and persists for several days, it is advisable to prevent the patient from the risks of haemorrhage which may occur in the event of surgery Minor (eg dental extraction).

Acetylsalicylic acid modifies: uricemia (analgesic dose, acetylsalicylic acid increases uricemia by inhibition, excretion of uric acid, at the doses used, in rheumatology, acetylsalicylic acid has an effect; Uricosuric).

At high doses used in rheumatology (anti-inflammatory doses), it is recommended to monitor the appearance of signs of overdose. In the event of the occurrence of ringing in the ears, loss of hearing and vertigo, the treatment modalities shall be re-evaluated.

In children, it is recommended to monitor salicylemia especially during start-up, treatment.

This medicine contains lactose and is not recommended for use in patients with galactose intolerance, Lapp lactase deficiency or malabsorption syndrome, glucose or galactose (hereditary or rare diseases). Br>

The 500 mg sachets are not suitable for children under 30 kg for indication of mild to moderate and / or febrile conditions and to children under 20 kg for Rheumatic conditions. There exists for these children dosages better adapted.

The use of this medication is not recommended in case of breast-feeding (see section Pregnancy and lactation).
The concomitant intake of acetylsalicylic acid is discouraged with

· Oral anticoagulants, for analgesic or antipyretic doses (≥ 500mg per dose and / or ≤3 g per day) of acetylsalicylic acid and in a patient with no history of ulcer, gastro- (See Interactions with other medicinal products and other forms of interaction)

· Oral anticoagulants for antiaggregating doses of acetylsalicylic acid (50 mg to 375 mg per day) and in a patient with a history of peptic ulcer disease (see section Interactions with other medicinal products And other forms of interactions)

Anti-inflammatory drugs (≥ 1 g per dose and / or ≥ 3 g daily), analgesics or antipyretics (≥ 500 mg per dose and / or ≤ 3 g per day) Of acetylsalicylic acid

Clopidogrel (apart from validated indications for this association in acute coronary syndrome)

Glucocorticoids (except hydrocortisone for treatment, replacement) for anti-inflammatory doses (≥ 1 g per dose, and / or ≥ 3 g per day) of acetylsalicylic acid (see section Interactions with other medicinal products and other ; Forms of interactions)

· Heparins of low molecular weight (and related) and unfractionated heparins, curative doses and / or elderly and for doses, anti-inflammatory drugs (≥ 1 g per dose and / or ≥ 3 g per day) or analgesics Or antipyretic drugs (≥ 500mg per dose and / or