Curative treatment of vitamin A deficiency


Oral use.

1 to 2 capsules per dose every 10 days until the liver stock is restored normal without unnecessarily prolonging the treatment so as to avoid chronic intoxication (see section 4.3) Br>

The capsules must be swallowed, such as with a glass of water.
Class: Pharmacotherapeutic: VITAMIN A, ATC code, A11CA01

(A: Digestive System and Metabolism)

Vitamin A is a vitamin, fat-soluble. It plays an important role in the formation of retinal purple (necessary for the adaptation of vision when light decreases), in cell multiplication and trophicity, epithelial and tissue.

· Hypersensitivity to one of the constituents

· Lipid absorption disorders

· Chronic malabsorption

· Associated therapeutics interfering with the absorption of vitamin A.

This medication is generally not recommended in case of breast-feeding (see section Pregnancy and lactation).
This medicine contains sorbitol. Its use is not recommended in patients with fructose intolerance

Due to the presence of sorbitol, this medicine may cause a moderate laxative effect.
To avoid overdosage, take into account the total doses of vitamin A in the case of combination of several treatments containing this vitamin.


In case of intake of 10 000 IU / day and more, risk of intracranial hypertension.


Risk of symptoms suggestive of hypervitaminosis A.

Clinical signs of acute overdosage in vitamin A (doses above 150,000 IU): disorders, digestive, headache, hypertension, intracranial (manifested in the infant by the fontanelle bulge), papillary edema, , Irritability, even convulsions, delayed generalized desquamation

Clinical signs of chronic overdose Vitamin A (risk of chronic poisoning during a prolonged intake of vitamin A in doses, supraphysiological in a non-deficient subject): hypertension, intracranial hyperostosis cortical long bones and welding Early epiphysis. The diagnosis is usually based on the finding of sensitive or painful subcutaneous swelling at the extremities of the limbs. The radiographs demonstrate a diaphyseal periosteal thickening at the level of the ulna, the fibula, the clavicles and the ribs.

Vitamin A is teratogenic in animals on several species.

In the human species, cases of malformations have been reported with high doses. However, to date, the absence of reliable epidemiological studies and the low number of individual notifications preclude concluding that this is indeed a malformative event.
< Br>
As a result, vitamin A in high doses will only be prescribed during pregnancy if there is a known deficiency


The use is not recommended in case of breast-feeding because of the risk of overdose in the newborn

Any adverse reaction is likely to be a manifestation of overdose and should result in discontinuation of treatment.
Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorization of the drug is important. It permits continuous monitoring of the benefit / risk ratio of the drug. Health professionals must report any adverse reactions suspected through the national reporting system: National Agency for the Safety of Medicines and Health Products (Ansm) and Network of Regional Centers for Pharmacovigilance.

Curative treatment of vitamin A deficiency