· Treatment of symptomatic hyperuricemia, primary or secondary (hemopathies, nephropathies, hyperuricemia, iatrogen)

· Treatment of gout: drop tophaceous, gout attack, recurrent, uratic arthropathy even when accompanied by hyperuraturia, uric lithiasis or renal insufficiency
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· Treatment of hyperuricuria and hyperuritis.

· Treatment and prevention of uric stones.

· Prevention of recurrences of calcium lithiasis in hyperuricemic or hyperuricuric patients, in addition to the usual dietary precautions, notably concerning the protein and calcium rations.
Dosage

The usual dosage should be determined according to the uricemia which should be regularly monitored.
In adults, the usual dosage varies from 2 to 10 mg / kg / day, ie 100 to 200 mg per day in mild cases, 300 to 600 mg per day in moderate cases or 700 to 900 mg per day In severe cases

In children, the usual dosage varies from 10 to 20 mg / kg / day without exceeding the dose of 400 mg per day divided into 3 doses
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It is recommended before prescription to seek renal insufficiency, especially in the elderly

The dosage should be adjusted according to the clearance of creatinine.
Creatinine clearance

Recommended maximum dose

80
An elevation of uric acid is frequently observed during pregnancy toxemias but does not require specific treatment.

Therefore, the use of allopurinol is discouraged during pregnancy This is not the systematic argument for advising a termination of pregnancy, but leads to an attitude of caution and a prenatal-oriented surveillance.

Breastfeeding

This medicinal product is added to a non-negligible quantity in breast milk and is therefore contraindicated in the case of breast-feeding.
The frequency of these undesirable effects has been established from post-marketing data.
The following undesirable effects are classified by system organ and by frequency according to the following convention

Very common

≥ 1/10 (≥ 10%)

Common

≥ 1/100 and