Treatment of outbreaks of localized cold sores (also called “cold sores”).
Pathway, cutaneous.

Reserved for adults and children over the age of 6.

Apply the cream, 5 times a day, to herpetic lesions sitting exclusively at the level of the lips, each application being spaced at least 3 to 4 hours apart and without application at night. It is recommended to apply the cream by overflowing widely around the lesions.

Treatment is more effective if it is started as early as the first symptoms,
The duration of the treatment should not exceed 5 days, without medical advice.

How to use the pump

It is recommended to carry out at least 3 to 4 slow and complete pressures in order to perfectly prime the pumping device as soon as it is first used and thus to ensure optimum delivery of the product
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ATC code: D06BB03

In order to be active, aciclovir must be phosphorylated to aciclovir triphosphate.
Only cells infected with herpes virus can carry out this phosphorylation by means of a viral enzyme.
Aciclovir triphosphate selectively inhibits viral DNA polymerase. The sequence of these two selective steps makes it possible to inhibit viral multiplication without interfering with normal cellular metabolism.
Aciclovir does not eradicate latent viruses

There are no data on the effects on the ability to drive and use machines

· Child under 6 years of age.

A history of hypersensitivity to aciclovir with valaciclovir, propylene glycol or any of the other excipients

Aciclovir cream is not recommended for use on mucous membranes such as the mouth, eye and vagina as it may be irritating

Precautions should be taken to avoid the accidental introduction of the cream into the eye.

For severely immunocompromised patients (eg, patients with AIDS or patients with bone marrow transplant), oral administration of aciclovir should be considered. These patients should consult a physician regarding the treatment of any infection

The excipient propylene glycol may cause irritation of the skin and alcohol, ketostearyl may induce local skin reactions (eg contact dermatitis).

No clinically significant interaction was identified.
Not applicable.

There are no expected adverse effects if the entire contents of a cream tube (2 g tube) is ingested orally.


The analysis of a midwife exposed to aciclovir did not reveal any malformative or fetotoxic effect, particularly aciclovir.

Accordingly, the use of aciclovir by the dermal route is possible in women, pregnant in accordance with the indications.


If maternal conditions permit, breast-feeding is possible when treated with this medication.

The following convention was used for the classification of undesirable effects according to their frequency

Very common (≥ 1/10), frequent (≥ 1/100 and